PHARMACOLOGICAL EVALUATION OF THE ANTINOCICEPTIVE AND ANTIINFLAMMATORY ACTIVITY OF THE SPECIES ENDOPLEURA UCHI

Resumo

The use of plants for medicinal purposes for the treatment, cure and prevention of diseases is one of the oldest forms of medicinal practice in humanity, where the Amazon region has a huge variety of plant species, which are used for medicinal purposes. An example is Endopleura uchi, popularly known as “yellow uchi”, used in the form of tea made from the bark, as it performs anti-inflammatory and antioxidant actions, among others. Based on popular knowledge about the medicinal use of the species, this study aimed to evaluate the anti-inflammatory and antinociceptive activities and perform the phytochemical screening of the hydroethanolic extract of the bark of the species Endopleura uchi (HEEu). In the phytochemical screening, both the hydroethanolic extract and the raw material were used and the presence of phenolic compounds, tannins and saponins can be found. To evaluate the antiinflammatory activity, the method of paw edema induced by carrageenan was used, and to evaluate the antinociceptive activity, the test of abdominal writhing induced by acetic acid was used. The rota-rod test was used to assess whether the extract interferes with the animals' motor coordination. Thus, the presence of secondary metabolites was detected and anti-inflammatory and antinociceptive activity demonstrated.